Certified Diabetes Care and Education Specialist (CDCES) Practice Exam

What effect do GLP-1 receptor agonists typically have on weight?

1. Weight gain

2. Weight neutral

3. Weight loss

4. Unpredictable

The correct answer is: Weight loss

GLP-1 receptor agonists are known for their significant impact on weight management, typically resulting in weight loss. These medications mimic the incretin hormone GLP-1, which helps regulate appetite and food intake. By enhancing the secretion of insulin in response to meals and suppressing the release of glucagon, they can lead to a reduction in appetite and promote feelings of fullness. This effect results in individuals consuming fewer calories, ultimately contributing to weight loss over time. In studies, patients treated with GLP-1 receptor agonists often experience a notable decrease in body weight compared to those not receiving these medications. This effect is particularly beneficial for individuals with type 2 diabetes, as weight loss can improve glycemic control and reduce the risk of complications associated with obesity. Other options, such as weight gain or being weight neutral, do not accurately reflect the established outcomes associated with GLP-1 receptor agonists.